Status:
TERMINATED
Neuroimaging for Depression
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Beth Israel Deaconess Medical Center
Emory University
Conditions:
Depression
Eligibility:
All Genders
30-60 years
Phase:
NA
Brief Summary
The investigators seek to determine whether brain imaging techniques can be used to help detect depression, assess its severity, and/or monitor or predict responses to treatment. Subjects with minor o...
Detailed Description
Depression can significantly disrupt one's ability to function effectively and efficiently, and the associated performance deficits can seriously jeopardize space mission success. The incidence of ser...
Eligibility Criteria
Inclusion
- DSM-IV criteria for minor or major depression
- Written informed consent
- Age 30-60 years (age of individuals currently in the astronaut corps)
Exclusion
- Suicidal or homicidal ideation
- Women who are pregnant, breastfeeding, or women of childbearing potential who are not using a medically accepted means of contraception
- Known history of serious or unstable medical illness
- History of seizure disorder, brain injury, any history of known neurological disease
- Clinical or lab evidence of untreated hypothyroidism
- History or DSM-IV diagnosis of organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorder, patients with mood congruent or mood incongruent psychotic features, patients with substance use disorders (excluding alcohol and nicotine) active within the last 12 months
- Current use of other psychotropic drugs, including current use of benzodiazepines, hypnotics, anticonvulsants
- Patients who have failed to respond during the course of their current major depressive episode to at least two antidepressant trials
- Currently undergoing depression-focused psychotherapy
- Patients who have taken an investigational psychotropic drug within the past year
- Patient cannot safely enter the MRI scanning environment
- Latex allergy
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT00864630
Start Date
September 1 2010
End Date
December 1 2011
Last Update
May 24 2011
Active Locations (1)
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1
Massachusetts General Hospital
Charlestown, Massachusetts, United States, 02129