Status:
UNKNOWN
Expiratory Airflow Limitation in Subjects With Obesity
Lead Sponsor:
Medical Center Alkmaar
Conditions:
Obesity
Eligibility:
All Genders
25-60 years
Brief Summary
The purpose of this study is to investigate posture dependent small airway obstruction in subjects with obesity, and to study the capacity of FOT as a measurement tool for small airways obstruction.
Detailed Description
Obesity is a cause of dyspnea due to mechanical impairment of pulmonary ventilation. One of the causes of this impairment is expiratory flow limitation, which is related to decreased lung volume. As a...
Eligibility Criteria
Inclusion
- Inclusion Criteria obese population:
- Male/female, age 25-60
- BMI (body mass index) 30-40 kg/m2
- Non or ex smokers with \< 10 packyears
- Inclusion Criteria control population:
- Male/female, age 25-60
- BMI (body mass index) 18.5-25 kg/m2
- Non or ex smokers with \<10 packyears
- Exclusion Criteria obese population:
- Asthma
- COPD (FEV1/FVC\<0.70)
- Reversibility \>9% in FEV1 (400 microgram salbutamol)
- Other significant neuromuscular, cardiac or lung disease
- Exclusion Criteria control population:
- Asthma
- COPD (FEV1/FVC\<0.70)
- Other significant neuromuscular, cardiac or lung disease
- Reversibility \>9% in FEV1 (400 microgram salbutamol)
Exclusion
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00865293
Start Date
July 1 2008
Last Update
July 14 2009
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