Status:
COMPLETED
Coronary Blood Flow Regulation During General Anesthesia
Lead Sponsor:
Amsterdam UMC, location VUmc
Collaborating Sponsors:
Netherlands Heart Foundation
Conditions:
Myocardial Ischemia
Autonomic Neuropathy
Eligibility:
MALE
18-75 years
Brief Summary
The central hypothesis in the present project is that general anesthesia may alter autonomic control such that perioperative coronary blood flow (CBF) is significantly disturbed. These disturbances i...
Detailed Description
In response to intraoperative stress, increased autonomic sympathetic activity may alter myocardial oxygen demand. Under normal physiological circumstances, sympathetic stimulation increases myocardia...
Eligibility Criteria
Inclusion
- male
- age between 18-75 years
- scheduled for non-cardiac intermediate or high risk surgery
- for patient group 2: indication for thoracic epidural anesthesia
Exclusion
- neurosurgery
- known/documented cardiac disease
- (untreated) hypertension
- abnormal ECG or echocardiogram
- peripheral vascular disease
- renal disease requiring hemo- or peritoneal dialysis
- inability to perform transthoracic echocardiography
- medication interfering with presynaptic catecholamine uptake
- for patient group 2: contra-indication for thoracic epidural anesthesia (bleeding diathesis, infection at the puncture site, patient refusal, severe stenotic valvular disease)
- previous allergic reaction to echocardiographic contrast agents
- contraindications for the use of echocardiographic contrast agents
Key Trial Info
Start Date :
April 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00866801
Start Date
April 1 2009
End Date
October 1 2014
Last Update
October 14 2015
Active Locations (1)
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1
VU University Medical Center
Amsterdam, North Holland, Netherlands, 1007 MB