Status:
COMPLETED
PMRR-NO: Pulmonary Metabolic Radiation Response Versus Exhaled Nitric Oxide
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Gastrointestinal Disease
Esophageal Cancer
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
The goal of this clinical research study is to use a new breathing test that measures the amount of nitric oxide (NO) you exhale. Researchers want to compare your "NO" levels to the amount of inflamma...
Detailed Description
Lung Cancer Cohort: NO Breathing Test: If you agree to take part in this study, you will have a breathing test performed before starting radiation therapy, weekly during radiation therapy and, about...
Eligibility Criteria
Inclusion
- Patients with pathologic diagnosis of esophagus cancer.
- For the cohort 2, patients with the pathological diagnosis of lung cancer.
- For the cohort 3, patients with any pathological diagnosis of a thoracic malignancy.
- Patients must sign informed consent.
- Patients who will receive concurrent chemotherapy and radiation therapy will be undergoing PET-scan for restaging between 25 and 75 days after radio therapy.
- For Lung Cohort, patients who will receive concurrent chemotherapy and radiation therapy or greater or equal to 3 weeks of radiation therapy alone.
- For the Lung Cohort, participation in a PET-scan for restaging between 40-50 days after radiotherapy is required. 10 patients will receive a second PET-scan within 2-7 days as a test for reproducibility.
Exclusion
- Significant pleural effusion as evaluated by the attending Radiation Oncologist is excluded.
- Patients who received thoracic radiotherapy prior to the study.
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2014
Estimated Enrollment :
163 Patients enrolled
Trial Details
Trial ID
NCT00867477
Start Date
March 1 2009
End Date
August 1 2014
Last Update
August 28 2014
Active Locations (1)
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1
UT MD Anderson Cancer Center
Houston, Texas, United States, 77030