Status:
COMPLETED
Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy (TRANSACT)
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Kilimanjaro Christian Medical Centre, Tanzania
European Union
Conditions:
Uncomplicated Malaria
Eligibility:
All Genders
6-10 years
Phase:
NA
Brief Summary
Artemisinin combination therapy (ACT) with artemether lumefantrine (AL) is currently the first line treatment policy in Tanzania. AL is an efficacious drug that also has the capacity to reduce malaria...
Detailed Description
2.1 MALARIA AND ITS TRANSMISSION TO MOSQUITOES Malaria is the most important parasitic disease in the world. Approximately one fourth of the world population is at risk of contracting the disease, and...
Eligibility Criteria
Inclusion
- Age 6 months - 10 years
- Residents of research area (5 km around the clinic)
- Willingness to come for complete scheduled follow-up.
- Uncomplicated malaria with P. falciparum mono-infection
- Parasitaemia of 1000-200,000 parasites/ul
- Temperature \> 37.5°C and \< 39.5°C, or history of fever in previous 24 hours.
- No history of adverse reactions to AL
- Understanding of the procedures of the study by parent or guardian and willing to participate by signing informed consent forms.
Exclusion
- General signs of severe malaria
- Haemoglobin concentration \< 5g/dl
- Presence of disease other than malaria causing febrile conditions
- Mixed infection with P. malariae or other non-falciparum malaria species
- Unwilling to participate and sign informed consent forms.
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2010
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT00868465
Start Date
April 1 2009
End Date
May 1 2010
Last Update
June 7 2010
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
International Centre for Insect Physiology and Ecology - St. Judes Clinic
Mbita, Suba District, Kenya
2
Kilimanjaro Christian Medical Centre, Magugu Field Site
Moshi, Kilimanjaro, Tanzania