Status:
COMPLETED
Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep
Lead Sponsor:
University of Pittsburgh
Conditions:
Post-Traumatic Stress Disorder
Eligibility:
MALE
18-50 years
Brief Summary
The overarching aim of this Exploratory/Developmental Research Grant Award (R21) is to explore the neurobiological correlates of PTSD during REM sleep by using state-of-the science positron emission t...
Eligibility Criteria
Inclusion
- General
- Male OIF/OEF returnees between the ages of 18 and 45 years old
- Combat Exposure Scale score \> 17
- Not taking medications known to affect sleep or wake function for at least 2 weeks (6 weeks for fluoxetine).
- No history of trauma before age 18
- Specific Inclusion Criteria for Subjects with PTSD:
- Meet diagnostic criteria for current PTSD according to the CAPS-1
- CAPS-1 score is less than 80
- Specific Inclusion Criteria for Subjects without PTSD:
- Total CAPS-1 scores \< 17
- Does not meet criteria for PTSD
Exclusion
- Trauma occurred less than 3 months prior to study entry
- CES score \< 17
- Taking medications known to affect sleep and / or brain glucose metabolism
- Current diagnosis of depression as determined by the SCID or BDI score \> 13
- History of psychotic or bipolar disorder
- Current history (within 3 months) of substance or alcohol abuse as determined by the SCID
- Positive alcohol blood test at screening or during the PET protocol
- Significant or unstable acute or chronic medical conditions
- Other current sleep disorders, such as insufficient sleep syndrome, delayed sleep phase syndrome, narcolepsy, restless legs syndrome, periodic leg movement disorder, obstructive sleep apnea, and current night shift work, suspected during the structured interview. Individuals who are found to have a apnea-hypopnea index (AHI) \> 10 or an index of periodic leg movements with arousal \> 15 will be excluded.
- Presence of implanted devices such as cardiac pacemaker, aneurysm clip, ear implant, shrapnel, neurostimulators or other metal devices
- Fear of closed spaces
- Previous radiation. Due to the risk of radiation exposure, we will exclude subjects who have had PET scans or other radiotracer exposure in the previous year.
- History of open head injury.
Key Trial Info
Start Date :
March 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2011
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00871650
Start Date
March 1 2009
End Date
November 1 2011
Last Update
January 16 2013
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213