Status:
COMPLETED
Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit
Lead Sponsor:
University of Minnesota
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
25+ years
Phase:
PHASE4
Brief Summary
This study will determine the effectiveness of antidepressant medication in preventing depression and improving recovery in people who have been supported by mechanical ventilators in an intensive car...
Detailed Description
More than one third of all people admitted to ICUs in hospitals require mechanical ventilation for respiratory failure. Many people who survive after being on mechanical ventilation for a prolonged ti...
Eligibility Criteria
Inclusion
- Newly mechanically ventilated via an endotracheal tube
- Expected to remain intubated for at least 48 hours
- Fluent in English or Spanish
Exclusion
- Depression before admission to the ICU, as determined by a proxy interview
- Use of antidepressant medication within the last 2 weeks or a monoamine oxidase (MAO) inhibitor in the previous month
- History of suicide attempt
- Ventricular arrhythmias or a seizure requiring medication in the last 6 months
- History of retinal vascular proliferation or bleeding
- Migraine headaches treated with 5-HT1 agonists
- Organ transplant within the last 6 months
- Score of less than 4 on the Glasgow coma scale, in the absence of drug effects, for 2 days
- Acute brain hemorrhage
- Increased intracranial pressure
- Active bleeding or less than 20,000 platelets/ul
- Expected prolonged inability to enterally administer escitalopram
- Residence more than 75 miles from study facility
- Serum sodium less than 125 mEq/l
- Hypersensitivity to citalopram or escitalopram
- Pregnant, breastfeeding, or possibly becoming pregnant in the next 3 months
- Undergoing life-support withdrawal or very low likelihood of 2-month survival
- Cognitive or communication impairment severe enough to preclude a conversation with an interviewer present before admission to ICU
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00872027
Start Date
April 1 2009
End Date
July 1 2011
Last Update
December 19 2017
Active Locations (1)
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1
University of Minnesota Medical Center
Minneapolis, Minnesota, United States, 55455