Status:
COMPLETED
Radiation Therapy and Docetaxel Followed by Standard Therapy in Treating Women With Breast Cancer
Lead Sponsor:
Centre Antoine Lacassagne
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Phase:
PHASE1
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in higher doses over a shorter period of time may kill more tumor cells and have fewer side effects. ...
Detailed Description
OBJECTIVES: Primary * Evaluate the tolerance to concurrent neoadjuvant docetaxel and cyberknife hypofractionated radiotherapy followed by standard treatment in women with breast cancer in order to f...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed diagnosis of breast cancer
- Unifocal disease
- Non-metastatic disease
- Not a candidate for breast-conserving surgery
- No superficial breast cancer (defined as the distance between tumor and skin ≤ 1 cm)
- Undergone MRI of the breast to define the macroscopic tumor volume
- Undergone scanning of the breast to mark the location for radiotherapy
- PATIENT CHARACTERISTICS:
- WHO performance status 0-2
- Not pregnant or nursing
- Fertile patients must use effective contraception during and for 6 months after completion of study treatment
- No counter-indications to surgery, standard neoadjuvant chemotherapy, or insertion of an implantable venous device
- No patient for whom clinical follow up is impossible for psychological, familial, social, or geographical reasons
- No patients deprived of liberty or under trusteeship
- PRIOR CONCURRENT THERAPY:
- No prior ipsilateral breast irradiation
Exclusion
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00872625
Start Date
April 1 2007
End Date
December 1 2010
Last Update
September 30 2025
Active Locations (1)
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1
Centre Antoine Lacassagne
Nice, France, 06189