Status:
COMPLETED
Nutrition and Exercise for Sarcopenia
Lead Sponsor:
The University of Texas Medical Branch, Galveston
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Sarcopenia
Eligibility:
All Genders
65-85 years
Phase:
PHASE1
Brief Summary
The investigators' general hypothesis is that nutritional factors, including protein/energy malnutrition and/or an impaired response of muscle to nutrition, and inactivity play significant roles in de...
Detailed Description
Our preliminary studies indicate that, in older adults, muscle protein anabolism is normally stimulated by amino acids alone, but impaired when nutritional stimuli contain carbohydrate due to a relati...
Eligibility Criteria
Inclusion
- age 65-85 yrs
- ability to sign consent form (score \>25 on the 30 item Mini Mental State Examination, MMSE)
- stable body weight for at least 1 year (verified via medical records).
Exclusion
- physical dependence or frailty (impairment in any of the Activities of Daily Living (ADL), history of falls (≥2/year) or significant weight loss in the past year)
- exercise training (≥2 weekly sessions of moderate-to-high intensity aerobic or resistance exercise)
- significant heart, liver, kidney, blood or respiratory disease
- peripheral vascular disease
- diabetes or other untreated endocrine disease
- active cancer
- recent (within 6 months) treatment with anabolic steroids, or corticosteroids
- alcohol or drug abuse
- tobacco use (smoking or chewing, verified via medical records)
- depression (\>5 on the 15-item Geriatric Depression Scale (GDS))
- malnutrition (BMI \<20 kg/m2; hypoalbuminemia or hypotransferrenemia; protein intake\<0.66 g/kg/day at run-in)
- obesity (BMI\>30 kg/m2).
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT00872911
Start Date
March 1 2009
End Date
August 1 2016
Last Update
December 12 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Sealy Center on Aging, University of Texas Medical Branch
Galveston, Texas, United States, 77550