Status:
COMPLETED
Treatment's Duration of Acute Uncomplicated Pyelonephritis
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Urinary Tract Infection
Fever
Eligibility:
FEMALE
18-65 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the efficacy of 5 days versus 10 days treatment duration in uncomplicated acute pyelonephritis. Acute pyelonephritis is a common disease and the treatment dura...
Detailed Description
1. State of the issue and objective of the research The acute pyelonephritis (AP) represent the most frequent COMMUNAUTARY bacterial infection. Currently, usual recommended duration of antibiotherapy ...
Eligibility Criteria
Inclusion
- Women 18 to 65 years old
- Non-immunocompromised
- Conducting a medical examination prior
- Signature of informed consent in writing.
- Clinical signs of urinary tract infection (urinary burning, urgency, pollakiuria, dysuria, pyuria, lumbar or pelvic pain),
- A temperature\> 38 ° C,
- A positive ECBU direct seed (s) sensitive (s) to the fluoroquinolones
Exclusion
- Antibiotic therapy prior
- Presence of complications of PNA (abscesses, dilated excretory pathways, probe urinary bladder, neurological, transplant, kidney single functional or anatomical),
- An episode of PNA within 6 months,
- having fluoroquinolones in 6 months,
- Infection on urinary endo-material (prosthetic urethral, ureteral probe)
- The immunodepressed (known seropositivity for HIV, asplenia, diabetes neutropenia, agammaglobulinemia ...)
- Pregnancy and lactation,
- Allergy to antibiotics,
- Corticosteroids concomitantly taking fluoroquinolones,
- History of TENDINOPATHY with a fluoroquinolone
- History of epilepsy
- Deficit known as glucose-6-phosphate dehydrogenase
- Life expectancy \<1 month
- Cognitive major
- Patient under guardianship, CURATORSHIP or without coverage,
- The need for immunosuppressive or corticosteroid therapy,
- The need for other concomitant antibiotic treatment, whatever the cause
- No affiliation to a social security scheme (beneficiary or beneficiary).
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
310 Patients enrolled
Trial Details
Trial ID
NCT00873626
Start Date
June 1 2009
End Date
August 1 2011
Last Update
November 6 2014
Active Locations (2)
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1
University hospital of Garches
Garches, France, 92380
2
university hospital of TOURS
Tours, France