Status:
TERMINATED
A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Alzheimer's Disease
Dementia
Eligibility:
All Genders
65+ years
Phase:
PHASE1
Brief Summary
This study will evaluate acute symptomatic improvements in cognitive performance in healthy elderly participants with mild-to-moderate Alzheimer's disease. A four-week pilot study will first evaluate ...
Eligibility Criteria
Inclusion
- Patient Specific:
- Female is not of reproductive potential
- Male who has a female partner(s) of child bearing potential, agrees to use acceptable method of contraception during the study
- Has at least 10 years of education or work history
- Has been a nonsmoker or has not used nicotine for at least 6 months
- Has a diagnosis of mild-to-moderate Alzheimer's Disease
- Has a reliable caregiver who consents to accompany the patient to all clinic visits, provide information to the study staff, and return for follow-up visits and procedures
- Healthy Elderly Volunteer Specific:
- Is in good general health
- Has no clinically significant abnormality on electrocardiogram (ECG)
Exclusion
- Participant Specific:
- Has a history of a neurological disorder other than Alzheimer's disease
- Is living in a nursing home
- Has a history of stroke
- Has a history of psychotic disorder, an active major depressive disorder, or history of schizophrenia
- Has a history of a sleep disorder
- Has a history of a cardiovascular disorder
- Has a history of malignancy
- Is participating or has participated in a study with an investigational compound, device, or vaccine for Alzheimer's disease
- Consumes greater than 6 servings of caffeine (coffee, tea or cola etc.) per day
- Consumes greater than 3 alcoholic beverages per day
- Has had major surgery, donated or loss blood in past 8 weeks
- Healthy Elderly Volunteer Specific:
- Is mentally or legally incapacitated, has significant emotional problems, or has a history of a psychiatric disorder over the last 5-10 years
Key Trial Info
Start Date :
April 6 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 20 2009
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT00874939
Start Date
April 6 2009
End Date
April 20 2009
Last Update
October 17 2018
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.