Status:
COMPLETED
Efficacy of Minoxidil in Children With Williams-Beuren Syndrome
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Williams Beuren Syndrome
Eligibility:
All Genders
6-18 years
Phase:
PHASE2
Brief Summary
The Williams-Beuren syndrome (WBS) is a sporadic congenital disorder characterized by a multisystem developmental impairment. This syndrome is caused by a microdeletion in chromosome 7q11.23 that enco...
Eligibility Criteria
Inclusion
- proven diagnosis of Williams Beuren syndrome (genetic test)
- normotension or hypertension, treated or not
- male or female,
- 6\< age \<18,
- negative pregnancy test for childbearing potential female
- effective birth control for sexually active female
- signed consent form collected from parents or legal guardian
Exclusion
- pulmonary hypertension secondary to mitral stenosis
- myocardial infarction within 1 month prior randomization
- known allergies to minoxidil or any of the components of Lonoten.
- asthma
- renal failure (creatinine clearance \<40ml/min)
- no affiliation to a national health insurance program (social security)
- intolerance to lactose
- current vasodilator anti hypertensive treatment
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00876200
Start Date
March 1 2009
End Date
August 1 2015
Last Update
September 30 2025
Active Locations (18)
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1
Service de Cardiologie Pédiatrique, CHU Angers
Angers, France, 49033
2
Service de Cardiologie, Hôpital Saint-André, CHU Bordeaux
Bordeaux, France, 33075
3
Service de Néphrologie Pédiatrique, Hôpital Pellegrin, CHU Bordeaux
Bordeaux, France, 33076
4
Service de Génétique Médicale, Hôpital Pellegrin, CHU Bordeaux
Bordeaux, France