Status:
COMPLETED
Disulfiram Interactions With HIV Medications: Clinical Implications
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
HIV Infections
Drug Abuse
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine whether disulfiram might be a safe and effective treatment for cocaine and/or alcohol dependence in patients with HIV disease. This research is designed to ch...
Detailed Description
Cocaine and alcohol abuse are strongly linked to HIV infection and transmission of the virus. Disulfiram has long been approved by the US FDA for the treatment of alcohol and recent data shows it to b...
Eligibility Criteria
Inclusion
- Good health and without clinical findings that require medical or psychiatric intervention as determined by a physical and mental status examination and screening laboratory tests, urinalysis, and ECG
- 18 years of age or older
- Willing to abstain from alcohol during the study and for two weeks afterward
Exclusion
- Patients who are receiving concurrently other drugs that are inducers or inhibitors of hepatic microsomal enzymes
- Patients with a known sensitivity to the HIV therapeutics to be studied
- Pregnant or nursing mothers
- Current major affective or psychotic illnesses or suicidality
- Clinically active hepatitis
- Diabetes, hyperlipidemia, coagulation disorders, or renal disease will be excluded
- Those meeting criteria for current alcohol or drug dependence (other than nicotine)
- HIV infection
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2013
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00878306
Start Date
November 1 2008
End Date
April 1 2013
Last Update
May 6 2014
Active Locations (1)
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1
San Francisco General Hospital
San Francisco, California, United States, 94110