Status:
COMPLETED
Losartan in Treating Patients With Idiopathic Pulmonary Fibrosis
Lead Sponsor:
University of South Florida
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Precancerous Condition
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
RATIONALE: Losartan may be effective in treating patients with idiopathic pulmonary fibrosis. PURPOSE: This clinical trial is studying the side effects of losartan and to see how well it works in tre...
Detailed Description
OBJECTIVES: * Evaluate the effects of losartan potassium on disease progression in patients with idiopathic pulmonary fibrosis. * Determine the safety of this drug in these patients. OUTLINE: This i...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age \> 21 years
- Diagnosis of idiopathic pulmonary fibrosis
- Patients taking Coumadin and/or N-acetylcysteine may participate in the study
- Baseline forced vital capacity (FVC) must be greater than or equal to 50%
- Baseline 6 minute walk test distance walked must be greater than or equal to 200 meters not requiring greater than 6 lpm of oxygen
- EXCLUSION CRITERIA:
- Pregnant, intending to become pregnant or breastfeeding
- Current or previous smoker of cigarettes or marijuana that recently quit within the last 6 months prior to enrollment
- Allergy or allergic reaction to Losartan or any other angiotensin II receptor blocker
- Taking losartan or any other angiotensin II receptor blocker
- Baseline systolic blood pressure \< 100 mmHg
- Currently taking or has taken immunosuppressant agents within the last month such as azathioprine, cyclophosphamide, colchicine and/or prednisone
- History of lung transplant
- History of kidney failure or liver disease
- Inability to attend clinic visits
Exclusion
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00879879
Start Date
March 1 2009
End Date
March 1 2012
Last Update
February 21 2021
Active Locations (1)
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1
University of Cincinnati
Cincinnati, Ohio, United States, 45267