Status:
UNKNOWN
The Dutch Acute Stroke Trial (DUST): Prediction of Outcome With Computed Tomography (CT) - Perfusion and CT-angiography
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
Dutch Heart Foundation
Conditions:
Acute Stroke
Eligibility:
All Genders
18+ years
Brief Summary
Less than 10% of all ischemic stroke patients are treated by intravenous thrombolysis (IVT) as most present later than the accepted 3 hour time window. Intra-arterial thrombolysis (IAT) is possible 3-...
Eligibility Criteria
Inclusion
- Acute neurological deficit caused by cerebral ischaemia
- Admission \< 9 hours after onset of neurological deficit
- NIH Stroke Scale (NIHSS) of at least 2
- No absolute contraindications against intravenous contrast
- Informed consent from patient or family after admission scan
- Patients who awaken with stroke symptoms can only be included if they went to sleep without any stroke symptoms and the time from going to sleep until imaging is less than 9 hours
Exclusion
- Neurological deficit caused by another diagnosis than cerebral ischaemia (such as intracerebral hemorrhage, subarachnoid hemorrhage or tumor)
- Patients with known contrast allergy or kidney failure
- Patients with the known combination of renal insufficiency and heart failure (New York Heart Association (NYHA) IV) will be excluded for the CTP and CTA scan at 3 days; they will have a non-contrast CT (NCCT) at that time.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
1500 Patients enrolled
Trial Details
Trial ID
NCT00880113
Start Date
May 1 2009
Last Update
June 5 2012
Active Locations (14)
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1
Academic Medical Center
Amsterdam, Netherlands
2
Onze Lieve Vrouwe Gasthuis (OLVG)
Amsterdam, Netherlands
3
VU Medical Center
Amsterdam, Netherlands
4
Gelre Hospitals
Apeldoorn, Netherlands