Status:
WITHDRAWN
Losartan in Treating Pulmonary Fibrosis in Patients With Stage I, II, or III Non-Small Cell Lung Cancer
Lead Sponsor:
University of South Florida
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Dyspnea
Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
RATIONALE: Losartan potassium may be effective in treating pulmonary fibrosis caused by radiation therapy in patients with non-small cell lung cancer. PURPOSE: This clinical trial is studying losarta...
Detailed Description
OBJECTIVES: Primary * To evaluate the effects of losartan potassium on the disease progression in patients with stage I-III non-small cell lung cancer and radiation-induced pulmonary fibrosis. * To ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- At least 18 years of age or older
- Diagnosed with non-small cell lung cancer stage I, II, IIIa, or IIIb
- Diagnosis of radiation-induced pulmonary fibrosis (as defined by National Cancer Institute's Common Terminology Criteria for Adverse Events \[CTCAE\] V3.0 Grade I to Grade III) and within 2 years of the last radiation therapy treatment
- EXCLUSION CRITERIA:
- Patients with a pneumonectomy
- Allergy or allergic reaction to Losartan or any other angiotensin II receptor blocker
- Use of an angiotensin II receptor blocker currently or within 6 months of study entry which include: losartan, valsartan, irbesartan, candesartan, cilexetil, eprosartan mesylate, and telmisartan
- Bilateral renal artery stenosis, hereditary or idiopathic angioedema, or uncontrolled hypotension
- Patients taking lithium
- Currently smoking or smoked within 6 months of study entry
- Pregnant, intending to become pregnant or breastfeeding
- Baseline systolic blood pressure \< 100 mmHg
- History of lung transplant
- History of kidney failure or liver disease
- Inability to attend clinic visits
Exclusion
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00880386
Start Date
March 1 2009
End Date
April 1 2010
Last Update
May 2 2017
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