Status:
COMPLETED
Race, Menopause and Metabolism After Exercise and Diet
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Obesity
Insulin Resistance
Eligibility:
FEMALE
45-80 years
Phase:
NA
Brief Summary
The purpose of this study is to test the hypotheses that there are ethnic and genetic differences in the mechanisms and magnitude by which hypocaloric weight loss and aerobic exercise affect body comp...
Detailed Description
The findings of this study will also determine whether there are racial differences in the whole body and cellular mechanisms by which aerobic exercise training and weight loss affect glucose, lipid, ...
Eligibility Criteria
Inclusion
- Female
- 45-80 yrs of age
- Non-smoking for one year
- BMI greater than 25 kg/m2 and less than 50 kg/m2
- Menopause over 1 year
- Caucasian or African American ethnicity
Exclusion
- Both groups
- Currently being treated for active cancer
- Type 1 diabetes; insulin treatment; poorly controlled (fasting blood sugar over 160 mg/dl)
- Allergic to lidocaine or heparin
- Untreated dyslipidemia, receiving triglyceride-lowering meds
- Other systemic disorders that are not medically treated and stable
- Taking beta-blockers, oral steroids, warfarin or any other medications interfering with fat/muscle metabolism that may not be safely discontinued temporarily for specific procedures (i.e. for 72 hours prior)
- Abnormal liver or renal function; chronic pulmonary disease (on supplemental oxygen); anemia
- MMSE (Mini-Mental State Examination) below 24, dementia or unstable clinical depression by exam
- Women of ethnicity other than Caucasian or African American
- Symptomatic heart disease, coronary artery disease, congestive heart failure, or uncontrolled hypertension unless medically stabilized
- Abnormal response to exercise test (chest pain, significant arrhythmias, extreme shortness of breath, cyanosis, exercising blood pressure above 240/120mm Hg, or other contraindications to exercise)
- Exercise plus weight loss group only
- Medical history of CVD (cardiovascular disease) with symptoms limiting ability to exercise
- Physical impairment limiting normal activity
- Aerobically trained with VO2max greater than 2 SD (standard deviation) above age-adjusted mean
Key Trial Info
Start Date :
March 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
103 Patients enrolled
Trial Details
Trial ID
NCT00882141
Start Date
March 1 2002
End Date
December 1 2008
Last Update
January 13 2010
Active Locations (1)
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1
University of Maryland, VAMC
Baltimore, Maryland, United States, 20705