Status:
COMPLETED
Treating Clozapine-induced Sinustachycardia With Bisoprolol
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Aalborg University Hospital
Aalborg University
Conditions:
Clozapine-induced Sinustachycardia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Clozapine-induced sinustachycardia occurs in 25% of patients treated with clozapine and sustained sinustachycardia might be a risk factor for dilated cardiomyopathy. This double-blinded cross over pla...
Eligibility Criteria
Inclusion
- Treated with clozapine \> 3 months and minimum 100 mg/day
- Fixed dose 14 days before inclusion
- Heart rate \> 100 (ECG)
- Pregnancy test negative
- Clozapine-induced sinustachycardia documented by ECG or case record
- Sexual abstinence or contraception
- Informed consent
Exclusion
- Substance abuse
- Physical diseases, contraindications for clozapine or bisoprolol
- Asthma or chronic obstructive lung disease
- Blood pressure \< 100/60 or recent history of syncopes
- QTc\>500 ms, SA-block, AV- block II or III
- Restrictions by Danish mental act
- Allergic to clozapine or bisoprolol
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00882856
Start Date
April 1 2009
End Date
December 1 2016
Last Update
January 9 2017
Active Locations (1)
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1
Aalborg University Hospital, Psychiatry
Aalborg, Denmark, 9000