Status:
COMPLETED
Myocardial Glucose Uptake (MGU) in Patients With Chronic Kidney Disease
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
Amgen
Conditions:
Cardiomyopathy
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Brief Summary
This study examines patients with chronic kidney disease-related anemia and measures changes in the metabolism of the heart using FDG/PET scanning, before and 6 months after their health-care provider...
Eligibility Criteria
Inclusion
- Participant must receive care at the VAMHCS (VA Hospital) in Baltimore
- Diagnosed with CKD stage 3 to 5 (eGFR of 60 ml/min/1.73m2) and not expected to initiate renal replacement therapy within 6 months
- Anemia related CKD.
- The last 2 serum hemoglobin (Hb) values less than 11.0 gm/dl but greater than 8.0 gm/dl
- Greater than 18 years of age
- Assessed to be clinically stable by the clinician
Exclusion
- Need for hemodialysis, peritoneal dialysis, or transplantation at the time of enrollment or projected to start within 6 months after enrollment
- Low functional capacity including inability to walk a flight of stairs with a bag of groceries (NYHA Class III/IV Heart Failure)
- Prior erythropoietic agents within last 12 weeks
- TSAT \< 15% and not receiving the recommended dose for iron deficiency
- Uncontrolled hypertension defined as greater than 180 mm Hg systolic or 110 mm Hg diastolic
- Potentially "brittle" diabetes with the propensity for symptomatic hypoglycemia after a 6 hour fast
- New diagnosis or ongoing therapy for Cancer
- Pregnancy
Key Trial Info
Start Date :
May 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00883415
Start Date
May 1 2008
End Date
November 1 2012
Last Update
May 21 2020
Active Locations (1)
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1
Baltimore VA Medical Center
Baltimore, Maryland, United States, 21201