Status:
UNKNOWN
Concurrent Chemotherapy and Radiotherapy With Nitroglycerin in Patients With Locally Advanced Non-Small Cell Lung Cancer
Lead Sponsor:
National Institute of Cancerología
Conditions:
Locally Advanced Non Small-Cell Lung Canger
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Nitroglycerin will increase the effectiveness of treatment with induction chemotherapy and concurrent chemo-radiotherapy by reducing chemo-radio resistance through an increased oxygen pressure in tumo...
Detailed Description
Nitroglycerin decreases hypoxia-induced resistance to antitumor drugs due to inhibition of Hypoxia Inducible Factor alfa (HIF-1α), it increases oxygen pressure in tumoral tissue by augmenting tumor bl...
Eligibility Criteria
Inclusion
- Histopathologic diagnosis of non small-cell lung cancer
- Clinical stage IIIA and/or IIIB without pleural effusion
- ECOG functional status 0 or 1
- No renal function alteration (GFR \>50%)
- No hepatic function alteration (ALT and AST less than 2 times its normal value)
- Leucocytes more than 2,000/mcl
- Hemoglobin more than 10mg/dL
- Platelets more than 100,000/mcl
Exclusion
- Ischemic heart disease
- Abnormal electrocardiogram
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00886405
Start Date
July 1 2006
End Date
January 1 2010
Last Update
April 22 2009
Active Locations (1)
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1
National Institute of Cancerología
Mexico City, Mexico City, Mexico