Status:
COMPLETED
A Study to Investigate the Magnitude and Duration of Response of MK0954 Compared to Placebo in Patients With Hypertension (0954-021)(COMPLETED)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Hypertension
Eligibility:
All Genders
21+ years
Phase:
PHASE3
Brief Summary
The purpose of this study was to evaluate the magnitude and durations of the antihypertensive effects of losartan using ambulatory blood pressure monitoring (ABPM), and to evaluate the safety of losar...
Eligibility Criteria
Inclusion
- Non-black men and women with mild to moderate hypertension and within 30% of their ideal body weight
- Patient is in good general health
- Blood pressure at time of randomization is 95-115 mm Hg
Exclusion
- Secondary Hypertension or history of malignant hypertension
- History of stroke
- History of myocardial infarction
- Atrial flutter or atrial fibrillation
- History of congestive Heart failure
- Patient taking major psychotropic agent or anti-depressant
- Patient regularly uses NSAIDS or high dose aspirin
- Known positive test for HIV/AIDS or Hepatitis B
- Patient is being treated for acute ulcer disease
- Prior exposure to losartan
- Actively treated diabetes mellitus
- History of chronic liver disease
- Actively treated diabetes mellitus
- Any known bleeding or platelet disorder
- Absence of one kidney
- Women of childbearing potential
- Alcoholism or drug addiction
Key Trial Info
Start Date :
May 1 1991
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 1992
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT00886600
Start Date
May 1 1991
End Date
August 1 1992
Last Update
August 27 2015
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