Status:
COMPLETED
Pathogenesis of Physical Induced Urticarial Syndromes
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Hypersensitivity, Immediate
Autoinflammatory Syndromes
Eligibility:
All Genders
2-90 years
Brief Summary
Background: * Urticaria is a common itchy skin disorder that may occur spontaneously or on exposure to a physical trigger (called physical urticaria). * Researchers are studying the genetic basis of ...
Detailed Description
Urticaria is a common skin disorder that is classified according to its chronicity into acute and chronic forms. It may occur spontaneously or on exposure to a physical factor. In the latter case, the...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Affected subjects/guardian must:
- Be at least 2 years of age and no older than 90 years of age
- Have a history of a physical urticaria, which has been evaluated by the patient's healthcare practitioner.
- Provide copies of pertinent medical records and laboratory studies
- Have a health care provider outside of NIH
- Be willing to give informed consent
- Be willing to donate blood for sample storage to be used for future research
- Non-affected relatives/guardian must:
- Be at least 2 years of age and no older than 90 years of age
- Have a relative who is enrolled on this protocol and is known to have a documented history of a physical urticaria
- Not have a history of physical urticaria
- Be willing to give informed consent
- Be willing to donate blood for sample storage to be used for future research
- Healthy volunteers must:
- Be 18-65 years of age
- Be non-atopic (not have a history of allergic rhinitis, asthma, atopic dermatitis) per subject medical history
- Have the ability to give informed consent
- Be willing to donate blood for sample storage to be used for future research
- Not have a history of physical urticaria
- EXCLUSION CRITERIA:
- The following criteria apply to all subjects:
- Presence of conditions which, in the judgment of the investigator or the referring physician, may put the subject at undue risk, such as acute infection, severe thrombocytopenia (minimum platelet count of 30,000), or significant cardiovascular disease
- Any condition that in the view of the principal investigator (PI) would make the subject unsuitable for enrollment in this study
- History of HIV or other known immunodeficiency
- History or evidence of chronic Hepatitis B and/or C infection
- Pregnancy
Exclusion
Key Trial Info
Start Date :
June 17 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
173 Patients enrolled
Trial Details
Trial ID
NCT00887939
Start Date
June 17 2009
Last Update
January 8 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892