Status:
UNKNOWN
Deep Brain Stimulation (DBS) For Parkinson's Disease: Caudal Zona Incerta Versus Subthalamic Nucleus
Lead Sponsor:
Charite University, Berlin, Germany
Conditions:
Parkinson's Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The aim of this study is to analyze the effects of two different targets of deep brain stimulation: caudal Zona incerta and Nucleus subthalamicus. The present study will investigate the effects of DBS...
Detailed Description
Parkinson's Disease (PD) is a severe neurological movement disorder comprising the triad of symptoms of bradykinesia, rigidity and tremor. It can be effectively treated with dopaminergic replacement t...
Eligibility Criteria
Inclusion
- Idiopathic Parkinson's disease (criteria of the British Brain Bank: L-DOPA- or Apomorphin-sensitivity of more than 30% or typical Parkinsonian tremor while resting)
- duration of disease \> 18 months
- age between 18 and 75 Jahren
- relevant disablement in daily activities/ impairment despite medical mental therapy
- informed and signed consent of the patient
Exclusion
- major depression with suicidal thoughts (Becks Depressions Inventory-Score \> 25); depressions in the past are no exclusion criterion
- Mattis Dementia Rating Scale-score \< 130
- stereotactic brain operations in the past
- significant brain atrophy
- increased bleeding tendency
- reduced infection defense
- relevant cerebrovascular disease
- acute psychosis (benign and/or hallucinations in the past are no exclusion criterion)
- a physical and/or mental illness which is likely to affect the study procedures in a negative way (e.g., cancer with reduced life expectancy)
- abuse of drugs or alcohol
- female study participants of child- bearing age without adequate contraception
- women during pregnancy or lactation
- no sufficient knowledge of the German language to answer the questionnaires
- other surgical contraindications
- participation in another clinical trial
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2013
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00888095
Start Date
July 1 2010
End Date
July 1 2013
Last Update
July 22 2009
Active Locations (1)
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1
Department of Neurology and Neurosurgery
Berlin, Germany