Status:
COMPLETED
A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
MALE
18-45 years
Phase:
PHASE1
Brief Summary
This study will evaluate the effect of a single dose of sitagliptin on glucose dependent insulin secretion using a meal tolerance test (MTT) during a hyperglycemic clamp (HCG) procedure.
Eligibility Criteria
Inclusion
- Subject is an Asian Indian male between 18 to 45 years of age
- Subject is in good health
- Subject is a nonsmoker or has not used nicotine-containing products for six months
- Subject is willing to avoid strenuous activity
Exclusion
- Subject has a history of stroke, seizures, or major neurological disorders
- Subject has irritable bowel disease or recurrent nausea, vomiting, diarrhea, or abdominal pain
- Subject has a history of high blood pressure requiring treatment
- Subject has history of cancer
- Subject has a history of diabetes
Key Trial Info
Start Date :
May 12 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 21 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00888238
Start Date
May 12 2009
End Date
July 21 2009
Last Update
June 26 2018
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