Status:
UNKNOWN
Desvenlafaxine Succinate (DVS) for Major Depressive Disorder (MDD) in Midlife Men and Women
Lead Sponsor:
Hamilton Health Sciences Corporation
Collaborating Sponsors:
Wyeth is now a wholly owned subsidiary of Pfizer
St. Joseph's Healthcare Hamilton
Conditions:
Major Depressive Disorder
Menopausal Staging and Vasomotor Symptoms (for Females)
Eligibility:
All Genders
40-60 years
Phase:
PHASE3
Brief Summary
The main objective of this study is to characterize a range of brain activation symptoms associated with depression and response to treatment in midlife men and women with MDD, using MRI and functiona...
Detailed Description
Major Depressive Disorder (MDD) has been associated with morphological changes in the brain and changes in key brain areas. Studies have shown that antidepressant use may promote the normalization of ...
Eligibility Criteria
Inclusion
- men and women, aged 40-60 years
- diagnosis of MDD
- for women, perimenopausal or postmenopausal
Exclusion
- other DSM-IV axis I diagnosis other than MDD
- using psychotropic medications
- suicidal ideation, homicidal ideation, or psychotic symptoms
- presence of laboratory abnormalities at baseline visit
- presence of heart disease, liver disease, kidney disease, pulmonary disease, blood or bleeding disease, thyroid disease, GI disease, seizure or epilepsy, head injury, cancer, uterine fibroids or endometriosis, gynecologic surgeries (except caesarian sections), electroconvulsive therapies in the past 3 months, HIV+/AIDS
- in addition (for women): use of hormone replacement therapies, menstrual dysfunction, pregnancy or breastfeeding
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2012
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00888862
Start Date
June 1 2009
End Date
October 1 2012
Last Update
February 8 2012
Active Locations (1)
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1
Women's Health Concerns Clinic
Hamilton, Ontario, Canada, L8P 3B6