Status:
COMPLETED
Modulation of Central Hypersensitivity in Chronic Musculoskeletal Pain by Intravenous Tropisetron
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Pain
Chronic Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Chronic pain is associated with hypersensitivity of the central nervous system. The drug under investigation (tropisetron) has been shown in animal studies to attenuate central hypersensitivity. It ha...
Detailed Description
Background Prolonged afferent nociceptive input induces an increase in the excitability of central sensory neurons. The hyperexcitable neurons amplify the nociceptive signal, thereby producing an exa...
Eligibility Criteria
Inclusion
- Chronic musculoskeletal pain
- Pain duration at least 6 months
Exclusion
- Pregnancy
- Breast feeding
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00889499
Start Date
March 1 2009
End Date
April 1 2010
Last Update
March 24 2011
Active Locations (1)
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1
Dep. of Anesthesiology and Pain Therapy, Bern University Hospital, Inselspital
Bern, Switzerland, 3010