Status:
TERMINATED
Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for CVD Among Obese Adolescents
Lead Sponsor:
Maria Sandberg Westerstahl
Conditions:
Cardiovascular Diseases
Eligibility:
All Genders
13-19 years
Phase:
NA
Brief Summary
The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.
Detailed Description
Forty subjects will be assigned to the exercise intervention group, thirty to the metformin therapy group and thirty to the control group. Group I will be treated daily with metformin. Group II will p...
Eligibility Criteria
Inclusion
- Age 13-19 years old at inclusion date
- Obesity according to gender and age specific BMI (Cole 2000)
- Reduced nocturnal systolic blood pressure fall (\< 10%)
- Signed informed consent by patient and parents
Exclusion
- Cardiovascular disease
- Insulin dependent diabetes mellitus
- Patient on medications that are contraindicated during Metformin treatment
- Pregnancy
- Mental or physical conditions limiting the ability to participate
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00889876
Start Date
February 1 2009
End Date
December 1 2015
Last Update
April 4 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Karolinska Institutet, Karolinska University Hospital Huddinge
Stockholm, Sweden, 141 86