Status:
COMPLETED
Chronic Obstructive Pulmonary Disease (COPD) and Domestic Endotoxin (CODE)
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40-100 years
Brief Summary
This project aims to characterize the independent effect of domestic endotoxin exposure on health status, as well as pulmonary and systemic inflammation, in former smokers with COPD. Positive findings...
Eligibility Criteria
Inclusion
- Patient reported physician diagnosis of COPD/Chronic Bronchitis/Emphysema
- Cigarette Smoking \> 10 pack-years
- Age \> 40 years
- Has not smoked \> 1 year
- Post BD FEV1/FVC ≤ 70%
- Post BD FEV1 (% predicted) 30-80%
- Ability and willingness to provide consent
Exclusion
- Non- English speaking
- Planning to move or live away from the home during the study period
- Co-morbid illnesses such as:
- Current physician diagnosis of Asthma
- Other pulmonary diseases
- Systemic disease requiring treatment with immunosuppressive agents
- Known alpha-1 antitrypsin deficiency
- Occupational exposure with high endotoxin exposure
- Within the last 6 months Use of oral corticosteroids
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2014
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT00890136
Start Date
July 1 2008
End Date
November 1 2014
Last Update
June 25 2019
Active Locations (1)
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1
Karina Romero
Baltimore, Maryland, United States, 21231