Status:
COMPLETED
Evaluation of Limb-Girdle Muscular Dystrophy
Lead Sponsor:
Cooperative International Neuromuscular Research Group
Collaborating Sponsors:
Carolinas Medical Center lead study site
Conditions:
Becker Muscular Dystrophy
Limb-Girdle Muscular Dystrophy, Type 2A (Calpain-3 Deficiency)
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to understand the biochemistry of different types of Limb-Girdle Muscular Dystrophy (LGMD) and to determine appropriate outcome measures for future clinical treatment tria...
Detailed Description
Specific Aims: Aim 1: Evaluate integrity of the extracellular matrix in patients with LGMD by measuring serum growth factors and cytokines and compare these to a disease control (BMD) and normal volu...
Eligibility Criteria
Inclusion
- 18 years of age or older.
- Diagnosis of LGMD2I, LGMD2A, LGMD2B, or BMD as determined by muscle biopsy immunohistochemistry, immunoblotting, or molecular analysis.
- Able to travel to study site
- Normal controls will be recruited as either friends of the study participants or through separate recruitment.
Exclusion
- Unable to travel to study site.
- Do not have the diagnosis of LGMD2I, LGMD2A, LGMD2B, or BMD after review of clinical testing.
Key Trial Info
Start Date :
April 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2013
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00893334
Start Date
April 1 2009
End Date
December 1 2013
Last Update
March 7 2014
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
2
Carolinas Medical Center
Charlotte, North Carolina, United States