Status:
COMPLETED
Beta-glucan on Fecal Microflora in Polypectomized Patients
Lead Sponsor:
Harokopio University
Collaborating Sponsors:
JOTIS S.A. FOOD INDUSTRY, GREECE
Conditions:
Polypectomized Patients
Eligibility:
All Genders
20-75 years
Phase:
NA
Brief Summary
The aim of this study is to determine the effect of the potential prebiotic beta-glucan on the intestinal microflora, the bacterial enzyme activity (beta-glucuronidase and beta-glucosidase) in the fec...
Detailed Description
Prebiotics, such as short- and long-chain fructo-oligosaccharides are fermented by the microflora colonizing the gastrointestinal tract, and they selectively stimulate the growth or the activity of on...
Eligibility Criteria
Inclusion
- The subjects must have biopsy and histologically confirmed adenomatous polyps ≥ 1cm in size or ≥ 3 in number with moderate or severe dysplasia
Exclusion
- Subjects ≥ 75 years of age
- Subjects who are pregnant or desire to become pregnant during the study period
- Subjects who are considered to be poor clinic attendees
- Subjects who have been on antibiotics within the previous month or are likely to require antibiotics during the trial
- Subjects who consume prebiotics or probiotics within the previous month or are likely to require antibiotics during the trial
- Subjects with colon cancer
- Subjects with additional gastrointestinal disorders (e.g., Crohn's disease or ulcerative colitis)
- Subjects with malignancy or any end-stage organ disease
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT00893659
Start Date
January 1 2009
End Date
July 1 2015
Last Update
July 24 2015
Active Locations (1)
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1
Harokopio University
Athens, Attica, Greece, 17671