Status:
UNKNOWN
Leptin: a Therapeutic Option for Treating Catabolic States and Malnutrition in Critically Ill Patients
Lead Sponsor:
Hadassah Medical Organization
Collaborating Sponsors:
Hebrew University of Jerusalem
Conditions:
Systemic Inflammatory Response Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
Leptin is a hormone that plays a central role in food intake and energy balance. It is secreted by fat cells, released into the circulation and transported into the central nervous system (brain), whe...
Detailed Description
Patients admitted to the Medical Intensive Care Unit who comply with criteria for SIRS (Systemic inflammatory response syndrome) will be enrolled into the study. SIRS can be diagnosed when two or mor...
Eligibility Criteria
Inclusion
- All patients with Systemic Inflammatory Response Syndrome (SIRS).
- SIRS can be diagnosed when two or more of the following are present:
- Heart rate \> 90 beats per minute
- Body temperature \< 36 or \> 38°C
- Hyperventilation (high respiratory rate) \> 20 breaths per minute or, on blood gas, a PaCO2 \< 32 mm Hg or mechanically ventilated
- White blood cell count \< 4000 cells/mm3 or \> 12000 cells/mm3 (\< 4 x 109 or \> 12 x 109 cells/L), or the presence of greater than 10% immature neutrophils.
Exclusion
- Patients under 18, pregnant patients, patients who refuse to participate
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00893932
Start Date
August 1 2008
End Date
December 1 2009
Last Update
May 6 2009
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical ICU, Hadassah Medical Organization
Jerusalem, Israel, 91120