Status:
COMPLETED
Improving Lesion Detection in Children With Magnetic Resonance Imaging (MRI)-Negative Partial Epilepsy Using Diffusion Tensor Imaging
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Localization-related Epilepsy
Partial Epilepsy
Eligibility:
All Genders
6-18 years
Brief Summary
Focal cortical dysplasia is one of the most common lesions responsible for medically refractory epilepsy in the pediatric population. In patients with medically intractable epilepsy, surgery is the on...
Detailed Description
The aims of this study are firstly to identify DTI abnormalities in the white matter of children with MRI-negative partial epilepsy and MRI-visible FCD compared to normal controls; and secondly to det...
Eligibility Criteria
Inclusion
- MRI negative partial epilepsy group:
- Patients diagnosed with partial epilepsy according to the International League Against Epilepsy (ILAE) standard \[53\]
- MRI study reported as normal
- Age ranging from 6-18 years (DTI indices alter with myelination and the changes are most marked from birth to 4 years of age)
- MRI-visible FCD group:
- Patients diagnosed with partial epilepsy according to the ILAE standard \[53\]
- Visual assessment of MRI demonstrates one or more features of FCD
- Cortical thickening
- Alteration in sulci and gyri pattern, including deep sulci
- Blurring of gray-white matter transition
- T2 signal prolongation of the cortex and subcortical white matter
- High T1 signal in the cortex
- Age ranging from 6-18 years (DTI indices alter with myelination and the changes are most marked from birth to 4 years of age)
- Normal controls:
- Subjects with no history of neurological diseases
- Age ranging from 6-18 years (most children under the age of 6 years are unable to tolerate the MR examination without general anesthesia or sedation).
- No requirement of general anesthesia or sedation
Exclusion
- Subjects with contraindications for MR imaging (i.e. retained foreign bodies, implants)
- Subjects with claustrophobia
- Controls with a prior history of traumatic brain injury, neurological disorder, cerebral palsy, developmental delay or learning disability
- Controls who require general anesthesia or sedation
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00894478
Start Date
May 1 2009
End Date
May 1 2012
Last Update
September 10 2013
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada