Status:
COMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)
Lead Sponsor:
UCSF Benioff Children's Hospital Oakland
Collaborating Sponsors:
Dairy Management Inc.
Conditions:
Dyslipidemia
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of the study is to test whether increased saturated fat intake results in increased levels of larger LDL and HDL particles in individuals with LDL Pattern B.
Detailed Description
Increased saturated fat intake is known to elevate plasma levels of both low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), however, less is know regarding t...
Eligibility Criteria
Inclusion
- Men or postmenopausal woman between 18-70 yrs
- Body Mass Index between 25-35
- Blood pressure \<150/90
- Non smoking
- Agrees to consume no alcohol or dietary supplements during the study
- LDL Subclass Pattern B
- Total cholesterol and LDLC ≤95th percentile for sex and age
- Fasting triglycerides ≤ 500mg/dl
- Fasting blood sugar \< 126 mg/dl
- At least 3 months weight stable
Exclusion
- History of coronary heart disease, cerebrovascular disease, peripheral vascular disease, bleeding disorder, liver or renal disease, diabetes, lung disease, HIV, or cancer (other than skin) in the last 5 years
- Taking drugs known to affect lipid metabolism or hormones
- Abnormal thyroid stimulating hormone (TSH)
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00895141
Start Date
April 1 2009
End Date
April 1 2011
Last Update
January 14 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cholesterol Research Center
Berkeley, California, United States, 94705