Status:
TERMINATED
MRI in Finding Hypoxia in Patients Undergoing Chemo and Radiation for Head and Neck Cancer
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18-120 years
Phase:
PHASE1
Brief Summary
RATIONALE: Diagnostic procedures, such as functional MRI, may help measure oxygen levels in tumor cells and may help in planning cancer treatment. PURPOSE: This phase I trial is studying functional M...
Detailed Description
OBJECTIVES: * Determine the undertaken oxygen sensitive MRI for the detection of hypoxia in patients with Stage III-IV head and neck cancer. * Correlate MRI parameters with histology, gene expression...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed squamous cell carcinoma of the head and neck
- Stage III or IV disease
- Measurable disease
- Scheduled to undergo standard treatment including radiation therapy and chemotherapy
- Participation on study # 092004-010 for tissue procurement
- PATIENT CHARACTERISTICS:
- ECOG performance status 0-2
- Serum creatinine ≤ 1.5 OR creatinine clearance ≥ 40
- Body mass index ≤ 34 Kg/m\^2
- Not claustrophobic
- No other contraindications to MRI (i.e., implanted pacemaker device)
- Not pregnant or nursing
- Negative pregnancy test
- No allergy to gadolinium
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
July 8 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00896350
Start Date
July 8 2009
End Date
July 1 2012
Last Update
February 18 2019
Active Locations (1)
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1
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, United States, 75390