Status:
TERMINATED
Study of Stored Tumor Samples in Young Patients With Brain Tumors
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Brain and Central Nervous System Tumors
Eligibility:
All Genders
Up to 39 years
Brief Summary
This laboratory study is looking at stored tumor samples in young patients with brain tumors. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more a...
Detailed Description
The overall objective of this non-therapeutic protocol is to develop and molecularly characterize patient-derived orthotopic xenografts (PDOXs), organoids and in vitro models derived from medulloblast...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Tumor may be primary, progressive or recurrent CNS tumor including brain and/or spine. All tumor types will be included with a focus on medulloblastoma, HGNET, CNS embryonal tumors, gliomas, ependymoma, CPC and ATRT tumors. Low grade gliomas are currently very challenging to culture and implant but if techniques mature these will also be included. Although rare, patients with ATRT may present with a primary renal and CNS tumor. In these instances samples will be collected from both the kidney and CNS tumor for analysis if available.
- Tumor may be collected at surgery prior to histologic confirmation
- Age less than 40 years at the time of initial diagnosis.
- Enrollment in the current version of the institution's banking protocol
- Exclusion Criteria
- Diagnosis of tumor outside the central nervous system.
- Age greater than or equal to 40 years at the time of diagnosis
Exclusion
Key Trial Info
Start Date :
November 30 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 25 2025
Estimated Enrollment :
139 Patients enrolled
Trial Details
Trial ID
NCT00897286
Start Date
November 30 2004
End Date
September 25 2025
Last Update
October 17 2025
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105