Status:
COMPLETED
DNA Analysis of Tumor Tissue Samples From Patients With Human Papilloma Virus-Associated Cancer of the Oropharynx
Lead Sponsor:
Vanderbilt University Medical Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
Up to 120 years
Brief Summary
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE:...
Detailed Description
OBJECTIVES: * Analyze PIK3CA expression and mutation and p110α amplification and expression in tumor tissue samples from patients with human papilloma virus positive (HPV+) and human papilloma virus ...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Undergoing operative procedures for biopsy and/or resection of squamous cell carcinoma (SCC) of the oropharynx
- Tumor tissue sample available from the Head and Neck Tissue Repository and Clinical Database of Vanderbilt University
- No tumors with human papilloma virus (HPV) DNA sequences but no expression of E6
- PATIENT CHARACTERISTICS:
- See Disease Characteristics
- PRIOR CONCURRENT THERAPY:
- Not specified
Exclusion
Key Trial Info
Start Date :
April 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00897988
Start Date
April 1 2006
Last Update
March 14 2017
Active Locations (3)
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1
Vanderbilt-Ingram Cancer Center - Cool Springs
Nashville, Tennessee, United States, 37064
2
Vanderbilt-Ingram Cancer Center at Franklin
Nashville, Tennessee, United States, 37064
3
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States, 37232-6838