Status:
COMPLETED
Gene Expression in Tissue From Patients With Acute Lymphoblastic Leukemia
Lead Sponsor:
ECOG-ACRIN Cancer Research Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Leukemia
Eligibility:
All Genders
15-65 years
Brief Summary
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at gene ...
Detailed Description
OBJECTIVES: * Identify genes involved in specific biologic processes or molecular functions that contribute to the mechanisms by which the BCR/ABL tyrosine kinase induces a leukemic phenotype using R...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Confirmed diagnosis of acute lymphoblastic leukemia
- Tissue banked on protocol ECOG-2993 meeting the following criteria:
- Leukemic blast cell population immunophenotyped in detail (e.g., including CD25) in ECOG's Immunophenotyping Reference Laboratory
- Flow cytometric analysis of gated blast cells reveals association with the B-cell lineage
- Mononuclear cell fraction used for RNA isolation contains 75-99% blasts (median 85%)
- Negative for TEL/AML1, MLL/AF4, and E2A/PBX1 by qualitative reverse transcription-polymerase chain reaction (RT-PCR)
- No FLT3 gene mutations
- BCR/ABL-positive samples meeting the following criteria:
- Presence of t(9;22)(q34;q11) by standard cytogenetics
- Detection of either p190 BCR/ABL or p210 BCR/ABL transcripts by qualitative RT-PCR
- Patients with genetic risk factors must meet the following criterion:
- Only a normal diploid karyotype is present in ≥ 15 metaphases by standard cytogenetics
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- Not specified
Exclusion
Key Trial Info
Start Date :
October 26 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 19 2012
Estimated Enrollment :
137 Patients enrolled
Trial Details
Trial ID
NCT00898261
Start Date
October 26 2007
End Date
July 19 2012
Last Update
May 19 2017
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