Status:
COMPLETED
Biological Markers in Patients With Pancreatic Cancer Experiencing Weight Loss
Lead Sponsor:
Case Comprehensive Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Cachexia
Pancreatic Cancer
Eligibility:
All Genders
18+ years
Brief Summary
RATIONALE: Learning about biological markers in patients with pancreatic cancer and cachexia may help doctors predict patient outcome and may help the study of cancer in the future. PURPOSE: This lab...
Detailed Description
OBJECTIVES: * Compare levels of caspase-3 and phosphorylated Akt (pAkt) in the rectus abdominous muscle of patients with pancreatic cancer who are experiencing cachexia and are undergoing surgery for...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria:
- Diagnosis or suspicion of pancreatic cancer
- Any stage disease allowed
- At least 5% weight loss within the past 6 months
- Scheduled to undergo exploratory surgery
- Scheduled to undergo exploratory surgery for suspected nonmalignant condition
- No weight loss OR weight loss due to specific reason (e.g., bowel obstruction, infection, or nausea/vomiting)
- No cancer diagnosis other than primary pancreatic carcinoma
- PATIENT CHARACTERISTICS:
- ECOG performance status 0-3
- Life expectancy ≥ 12 weeks
- No pacemakers or implanted defibrillators
- PRIOR CONCURRENT THERAPY:
- Prior or concurrent chemotherapy and radiotherapy allowed
- Prior or concurrent biological therapy and surgery allowed
- At least 4 weeks since prior corticosteroids or anabolic steroids
- Other concurrent anticancer therapy allowed
- No concurrent corticosteroids or anabolic steroids, thalidomide, eicosapentaenoic acid (EPA), or Juven for weight loss
- Concurrent steroids (i.e., antiemetics) associated with chemotherapy allowed
- No concurrent nutritional supplements with EPA
Exclusion
Key Trial Info
Start Date :
June 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00899158
Start Date
June 1 2005
End Date
December 1 2008
Last Update
September 30 2015
Active Locations (1)
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1
Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106