Status:
COMPLETED
Microsphere-Delivered Cytokines in Increasing Tumor Response in Lymphocytes From Patients With Head and Neck Cancer
Lead Sponsor:
NYU Langone Health
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about how interleukin-2, interleukin-12, and GM-CSF delivered in microspheres increa...
Detailed Description
OBJECTIVES: * Determine whether local sustained delivery of cytokines (interleukin-2, interleukin-12, or sargramostim \[GM-CSF\]) in biodegradable microspheres augments antitumor response in human pe...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed squamous cell carcinoma of the head and neck
- Tumor tissue shows engraftment in severe combined immunodeficient (SCID) mice or growth in tissue culture
- PATIENT CHARACTERISTICS:
- Age
- 20 to 80
- Performance status
- Not specified
- Life expectancy
- Not specified
- Hematopoietic
- Not specified
- Hepatic
- Not specified
- Renal
- Not specified
- Other
- Not pregnant or nursing
- Fertile patients must use effective contraception
- No known immunocompromised disease or condition
- No social, physical, or psychiatric condition that would preclude leukapheresis
- PRIOR CONCURRENT THERAPY:
- Biologic therapy
- Not specified
- Chemotherapy
- Not specified
- Endocrine therapy
- Not specified
- Radiotherapy
- Not specified
- Surgery
- Not specified
- Other
- No concurrent immunosuppressive medication
Exclusion
Key Trial Info
Start Date :
June 1 2000
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00899821
Start Date
June 1 2000
Last Update
November 9 2012
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