Status:
COMPLETED
DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Brain Tumors
Central Nervous System Tumors
Eligibility:
All Genders
Up to 18 years
Brief Summary
This multi-institutional study will prospectively collect tumor and constitutional tissue samples from patients with diffuse brainstem glioma and other types of brainstem gliomas either during therapy...
Detailed Description
Since very little is known about the biology of diffuse brainstem glioma, the goal of this protocol is to undertake a systematic analysis of DNA abnormalities, and of RNA and protein expression in pro...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Patients of any age with clinical and radiologic diagnosis of diffuse brainstem glioma
- Patients with other high-grade gliomas originating in the brainstem
- Patients with focal gliomas (WHO grade I/II) of the brainstem
- Enrollment in the current version of the St. Jude Tissue Bank protocol for patients whose tissue samples were obtained at diagnosis and who received treatment at St. Jude Children's Research Hospital (SJCRH), or correspondent tissue banking consent for patients treated in other institutions if tissue was obtained prior to death (as applicable, depending on the standard of each institution)
- Exclusion Criteria
- Patients with any type of infiltrative low-grade (WHO grade II) or high-grade glioma (WHO grade III and IV) originating outside the brainstem
- Patients harboring primary brainstem tumors with other histologic diagnoses (e.g., PNET)
Exclusion
Key Trial Info
Start Date :
June 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT00899834
Start Date
June 1 2006
End Date
August 1 2015
Last Update
July 26 2016
Active Locations (3)
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1
Stanford University Medical Center
Palo Alto, California, United States, 94305
2
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
3
Seattle Children's Hospital
Seattle, Washington, United States, 98105