Status:
COMPLETED
Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant
Lead Sponsor:
Vanderbilt-Ingram Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Breast Cancer
Chronic Myeloproliferative Disorders
Eligibility:
All Genders
18+ years
Brief Summary
RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in...
Detailed Description
OBJECTIVES: * To establish a DNA bank from donor and recipient (prior to transplant) peripheral blood for SNP studies. * To establish a tissue bank for gene expression studies using donor and recipie...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Approved for allogeneic stem cell transplantation
- Sample of the stem cells from donor must meet 1 of the following criteria:
- Total peripheral blood stem cell dose \> 5 X10\^6 CD34+ cells/kg
- Marrow cell dose \> 3 X 10\^8 nucleated cells/kg
- PATIENT CHARACTERISTICS:
- Platelet count \> 50,000/mm³ (for patients undergoing endoscopic biopsies)
- INR \< 1.5 (for patients undergoing endoscopic biopsies)
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
190 Patients enrolled
Trial Details
Trial ID
NCT00900406
Start Date
January 1 2007
End Date
March 1 2010
Last Update
November 6 2012
Active Locations (3)
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1
Vanderbilt-Ingram Cancer Center - Cool Springs
Nashville, Tennessee, United States, 37064
2
Vanderbilt-Ingram Cancer Center at Franklin
Nashville, Tennessee, United States, 37064
3
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States, 37232-6838