Status:
COMPLETED
Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
NHS Lothian
British Heart Foundation
Conditions:
Heart Disease
Heart Failure
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many c...
Eligibility Criteria
Inclusion
- \>18yr
Exclusion
- Lack of informed consent
- Age \< 18 years,
- Current involvement in other research studies,
- Systolic blood pressure \>190 mmHg or \<100 mmHg
- Malignant arrhythmias
- Renal or hepatic failure
- Haemodynamically significant aortic stenosis
- Severe or significant co morbidity
- Women of childbearing potential.
- Any regular medication
- Previous history of any cardiovascular disease
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2010
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00901719
Start Date
April 1 2010
End Date
May 1 2010
Last Update
August 10 2010
Active Locations (1)
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1
Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc
Edinburgh, United Kingdom, EH16 4SA