Status:
COMPLETED
Immune Responses Induced by Different Licensed Influenza Vaccines
Lead Sponsor:
University of Massachusetts, Worcester
Conditions:
Immune Response
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this research is to find out how the body's immune system responds to different manufacturer's "flu" vaccines.
Detailed Description
There are currently five licensed inactivated influenza vaccines approved for use in the United States by the Food and Drug Administration.Current influenza virus vaccines consist of 3 components: the...
Eligibility Criteria
Inclusion
- Adults (18-50 years of age)
- Willing to donate a blood sample multiple times
- Willing to sign informed consent and HIPAA
Exclusion
- Known systemic hypersensitivity reactions to egg proteins (eggs or egg products), to chicken proteins
- Known hypersensitivity to neomycin, thimerosol (mercury derivative), neomycin, or polymyxin
- Previous life threatening reaction to influenza vaccine
- Individuals with altered immunocompetence state from medical condition ( HIV, cancer) or through immunosuppressive therapy(irradiation,corticosteroids, antimetabolites, alkylating agents, cytotoxic agents)
- Occurrence of neurological syndrome within six weeks of previous influenza immunization
- Active neurological disorder characterized by changing neurological disorder
- Pregnancy
- Acute febrile illness
- History of anemia or bleeding disorders
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2016
Estimated Enrollment :
193 Patients enrolled
Trial Details
Trial ID
NCT00902278
Start Date
October 1 2008
End Date
April 1 2016
Last Update
November 20 2017
Active Locations (1)
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1
University of Massachusetts Medical School
Worcester, Massachusetts, United States, 01605