Status:
COMPLETED
Deep Brain Stimulation of the Globus Pallidus in Huntington's Disease
Lead Sponsor:
Heinrich-Heine University, Duesseldorf
Conditions:
Huntington's Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This is a single centre, controlled phase I study, which evaluates safety and efficacy of stimulation of lower caudal two contacts (GPI) vs. upper cranial two contacts (GPE) in Huntington´s disease (H...
Detailed Description
A total of 6 HD patients will be selected out of an existing larger HD patient cohort upon careful evaluation of the inclusion and exclusion criteria at month 0. Patients will be recruited if no signi...
Eligibility Criteria
Inclusion
- clinically symptomatic and genetically confirmed Huntington Disease (number of CAG repeats\>= 36)
- age: \> 18
- moderate stage of the disease (UHDRS motor\>= 30)
- predominant movement disorder
- compliance of the patient, stable cognition during a 6 months phase prior to inclusion (MDS\>/= 120)
- signed informed consent
Exclusion
- advanced disease, precluding the ability to give informed consent
- very early stage of disease causing minor disability
- severe comorbidity that could compromise the life prognostic or preclude general anaesthesia or immunosuppression
- Mattis Dementia Rating Scale \< 120
- psychiatric or personality disturbances that might compromise the follow-up
- participation at another trial (in particular transplantation)
- severe cortical atrophy seen on CT and MRI
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT00902889
Start Date
May 1 2009
End Date
July 1 2012
Last Update
September 11 2012
Active Locations (1)
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1
Functional Neurosurgery and Stereotaxy, Department of Neurosurgery University Hospital Duesseldorf
Düsseldorf, North Rhine-Westphalia, Germany, 40225