Status:
COMPLETED
Low Dose Cyclosporin and Methotrexate Therapy in Diabetes
Lead Sponsor:
Georgetown University
Conditions:
Type 1 Diabetes Mellitus
Eligibility:
All Genders
8-18 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether treatment with low dose cyclosporin and methotrexate can inhibit the development of new onset diabetes mellitus
Detailed Description
Objective: Although high doses of cyclosporin (cyclo) inhibits the development of type 1 diabetes mellitus, its usefulness is limited by its toxicity. Since methotrexate (mtx) and cyclo synergisticall...
Eligibility Criteria
Inclusion
- Diagnosis of Type1 diabetes mellitus and be obtaining insulin therapy for less than 4 weeks
Exclusion
- Ketoacidosis
- Body weight over 110% of ideal weight
- Condition where immunosuppression is contraindicated
- Abnormal liver or renal function tests
Key Trial Info
Start Date :
February 1 1990
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 1994
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00905073
Start Date
February 1 1990
End Date
June 1 1994
Last Update
April 13 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Georgetown University
Washington D.C., District of Columbia, United States, 20007