Status:
COMPLETED
Self-guided Depression Treatment on Long-duration Spaceflights: A Continuation Study
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborating Sponsors:
Dartmouth-Hitchcock Medical Center
National Space Biomedical Research Institute
Conditions:
Depression
Eligibility:
All Genders
30-60 years
Phase:
NA
Brief Summary
Use of a computer-based treatment will reduce level of depression.
Detailed Description
Objective Depression can present a significant threat to long-duration space missions, and crews need the ability to recognize it and treat it effectively. We are developing a prototype computer-based...
Eligibility Criteria
Inclusion
- Criteria for matching to astronaut corps population:
- Completed 4 or more years of college or university education
- Age 30-60
- Has access to a personal computer and regularly uses it (at least twice per week)
- Clinical criteria:
- Score of 10 or higher on Hamilton Depression Inventory (which yields equivalent scores to the Hamilton Depression Rating Scale).
- Has a diagnosis of minor depression consisting of 2 to 4 DSM-IV symptoms of depression, one of which is depressed mood or anhedonia
- Presence of depressive symptoms for at least 2 weeks but less than 2 years
- Patient willing to avoid or postpone the use of antidepressant drugs during the treatment portion of the study (6 weeks)
Exclusion
- Presence of more severe depression or dysthymia within the past 6 months (to rule out persons currently remitting from major depression)
- Current or past diagnosis of organic mental disorder, schizophrenia, bipolar disorder, or current psychotic symptoms
- Current suicidal ideation or any history of suicide attempt or self-injurious behavior
- Presence of comorbid antisocial personality disorder
- Any current substance abuse/dependence (other than nicotine or caffeine)
- Suicidal ideation or parasuicidality
- Current homicidal ideation
- Recent regimen changes within the past 2 months in prescribed antidepressants, benzodiazepines, or buspirone
- Currently receiving psychotherapy or mental health counseling
- Exposure to PST in previous studies
- Moderate or sever cognitive impairment (Mini Mental State Score \<= 23)
- Near terminal medical illness (physician estimates \< 6 months to live)
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2009
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT00906581
Start Date
April 1 2009
End Date
September 1 2009
Last Update
April 13 2017
Active Locations (1)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02120