Status:
UNKNOWN
The Role of Angiopoietin, Tie-2, and Vascular Endothelial Growth Factor (VEGF) in Sepsis-Induced Multiple Organ Dysfunction Syndrome (MODS)
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Sepsis
Multiple Organ Dysfunction Syndrome
Eligibility:
All Genders
18-90 years
Brief Summary
This study is designated to determine serum concentrations of inflammatory mediators Ang-1, Ang-2, Ang-1/Ang-2 ratio, and Tie-2 in patients with sepsis-induced MODS and to investigate the association ...
Detailed Description
Multiple Organ Dysfunction Syndrome (MODS) frequently leads to death in patients with sepsis. Our previous work has demonstrated that endothelial injury is closely associated with MODS development and...
Eligibility Criteria
Inclusion
- Patients must have known origin of infection plus at least 2 of the following criteria of systemic inflammatory response syndrome:
- fever \> 38C or hypothermia \< 36C;
- heart rate \> 90 beats/ minute;
- respiratory rate \> 20 breaths/minute or PaCO2\< 32 mmHg or mechanical ventilation for an acute process;
- WBC count \> 12x109/L or \< 4x109/L or \> 10% immature neutrophils.
Exclusion
- Age less than 18 years,
- Pregnant,
- Inability to provide informed, written consent,
- Patients with urologic trauma resulting in frank hematuria, urinary infection, or existing chronic renal disease (serum creatinine level \> 2.0 mg/dL),
- Patients receiving nephrotoxic drugs, admitted to the hospital following a surgical procedure, or remaining in the ICU for \< 72 hours will be also excluded.
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2010
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00908635
Start Date
July 1 2008
End Date
August 1 2010
Last Update
May 27 2009
Active Locations (1)
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1
Chang Gung Memorial Hospital
Taoyuan District, Taiwan, 333