Status:
COMPLETED
Using Affective Differences to Predict Response to Behavioral Treatment for Major Depressive Disorder
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
University of Chicago
Conditions:
Depression
Eligibility:
All Genders
18-72 years
Brief Summary
This study will determine how people with depression differ from healthy people in brain activity and interpreting emotions, both before and after receiving a psychotherapy treatment.
Detailed Description
Major depressive disorder is a serious form of depression that may be treated with psychotherapy. However, up to 40% of adults with depression do not show reduced symptoms when treated with cognitive ...
Eligibility Criteria
Inclusion
- Healthy participants should have no lifetime history of psychiatric disorder
- Depressed participants should have a current diagnosis of major depressive disorder, as defined by the DSM-IV
Exclusion
- History of bipolar affective disorder
- History of psychosis
- Current non-psychotic Axis I disorder, if it constitutes the predominant aspect of the clinical presentation and immediately requires treatment other than that offered in the study
- History of substance dependence within the past 6 months
- Antisocial, borderline, schizotypal, or schizoid personality disorders
- Evidence of any medical disorder or condition that could cause depression or preclude the use of study treatments
- Current treatment with catecholaminergic antihypertensive medication, such as reserpine, beta-blockers, clonidine, and alphamethyldopa
- Current use of antidepressant medication
- Clear indication of secondary gain
- Current suicide risk sufficient to preclude treatment on an outpatient basis
- Severe, unstable concurrent psychiatric conditions likely to require hospitalization within 6 months of study entry
- Already receiving a targeted psychotherapy aimed at depression
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT00909220
Start Date
May 1 2009
End Date
April 1 2012
Last Update
April 17 2018
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