Status:
TERMINATED
Mobilization of Endothelial Progenitor Cells Induced by Atorvastatin in Patients With Stable Coronary Artery Disease Treated With Anti-CD 34 Antibodies Coated Stents
Lead Sponsor:
Fondazione IRCCS Policlinico San Matteo di Pavia
Conditions:
Stable Coronary Artery Disease
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to evaluate the extent of the mobilization of endothelial progenitor cells induced by low versus high dose atorvastatin after 4 weeks of treatment, in patients treated wit...
Detailed Description
Addition of statins to peripheral blood circulating mononuclear cells (PBMNCs) and to their CD 34+ subset cultures promotes endothelial progenitor cells (EPCs) proliferation, migration and survival ac...
Eligibility Criteria
Inclusion
- age between 18 and 75 years
- stable angina or silent ischemia
- documented CAD
- signed written informed consent
Exclusion
- current or recent therapy (stop \< 3 months) with statins
- allergy to ASA or ticlopidine/clopidogrel
- myocardial infarction (\< 3 months)
- recent significant trauma or surgical interventions (\< 3 mesi)
- significant renal or hepatic diseases
- coagulative-hematological disorders
- cancer
- inflammatory diseases
- myopathy
- pregnancy (a pregnancy test will be performed in fertile women)
- severe coronary calcification, or small vessels disease (\< 2.5 mm), long lesions (\> 20 mm), ostial lesions, bifurcation lesions requesting treatment of the collateral vessel, multi-vessel disease requiring PCI before the completion of the study
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 13 2021
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00911339
Start Date
January 1 2009
End Date
May 13 2021
Last Update
August 31 2021
Active Locations (1)
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1
Fondazione Irccs Policlinico San Matteo
Pavia, Italy, 27100