Status:
UNKNOWN
Donepezil Treatment for Sleep Apnea Patients
Lead Sponsor:
Associacao Fundo de Incentivo a Psicofarmcologia
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conditions:
Obstructive Sleep Apnea
Eligibility:
MALE
30-60 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine the effects of the anticholinesterase drug donepezil on sleep apnea patients. Sleep structure and respiratory parameters will be analyzed by polysomnography.
Detailed Description
Cholinergic activity also influences the upper airway opening via central and peripheral mechanisms. Decreased thalamic pontine cholinergic projections may affect respiratory drive leading to both cen...
Eligibility Criteria
Inclusion
- diagnosis of obstructive sleep apnea according to American Academy of Sleep Medicine criteria
Exclusion
- body mass index \> 40
- use of psychoactive drugs
- presence of neurological, cardiological and pulmonary diseases
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00912457
Start Date
March 1 2007
End Date
December 1 2009
Last Update
June 3 2009
Active Locations (1)
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1
Instituto do Sono / Associacao Fundo de Incentivo a Psicofarmacologia
São Paulo, São Paulo, Brazil, 04020-060